No result: For APOE, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

Exact input: For APOE, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

Execution template: clinvar gnomad ensembl

execution observatory

Attempt 1 of 1

failed Failed · publish stage

committed record

immutable execution contract

exact input: For APOE, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?
execution template: clinvar gnomad ensembl

scope
dataset
run
write
review
correct
publish

latest committed step

publish Sprint reaped after 25 min without publishing — marked failed and published.

run_failed · run · failed · reaper

committed steps: 30
accepted / verified: 2
warnings / rejects: 2
elapsed: 25 minutes
last recorded: about 3 hours ago
tokens recorded: not recorded
data downloaded: not recorded

retained execution history

Every attempt

Latest attempt

Attempt 1 failed Aug 1, 2026 · 09:25 No result: For APOE, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

canonical execution ledger

Every committed step

Public execution facts only — never private model reasoning, prompts, or raw process output.

attempt-1-ledger hal9000/run/81f62c77/1 chronological · persisted · archived Reload

001 09:00:00 orchestration run_queued run · queued · rails Execution attempt 1 queued.
002 09:00:00 triage investigation_selected notice · observed · rails Capability gate passed with clinvar_gnomad_ensembl. Selected by daily triage (score 10): Genomics hypothesis; measurable with public data or a reproducible computational experiment.

reason code

supported_template_match

reference template

clinvar_gnomad_ensembl
003 09:00:00 exploration neighbor_ideas_accepted artifact · accepted · rails Explored the seed idea and queued 0 undervalued hypotheses for future runs.

idea count

0
004 09:00:05 orchestration run_claimed run · claimed · rails Engine claimed this execution attempt.
005 09:00:05 orchestration runner_launch_authorized run · started · rails Execution lease acquired; the runner may launch once.
006 09:00:12 orchestration wrapper_started run · started · wrapper Opencode process started for this exact attempt.

timeout s

1200
007 09:01:39 scoping scope_started action · started · agent Beginning scoping for this exact execution attempt.
008 09:02:16 scoping scope_proposed gate · proposed · agent Proposed one falsifiable scoped question using the supported reference analysis.

question

For APOE versus the housekeeping gene B2M, is the gap in gnomAD population allele frequency between ClinVar pathogenic and benign variants larger for APOE (rank-based within-gene effect size of the ClinVar pathogenic-vs-benign comparison)?
009 09:02:23 data dataset_search_started action · started · agent Searching one bounded zero-auth public source.

accession

APOE+B2M lookup

source

Ensembl REST
010 09:02:25 data dataset_search_started action · started · agent Searching one bounded zero-auth public source.

accession

gnomad_r4 APOE+B2M

source

gnomAD GraphQL
011 09:02:28 data dataset_search_started action · started · agent Searching one bounded zero-auth public source.

accession

APOE+B2M gene

source

ClinVar NCBI E-utilities
012 09:02:54 data dataset_proposed artifact · proposed · agent Proposed a bounded dataset provenance record for terminal validation.

accession

ENSG00000130203/ENSG00000166710

bytes

851

source

Ensembl REST
013 09:02:57 data dataset_proposed artifact · proposed · agent Proposed a bounded dataset provenance record for terminal validation.

accession

ENSG00000130203/ENSG00000166710

bytes

333546

source

gnomAD (gnomad_r4)
014 09:03:00 data dataset_proposed artifact · proposed · agent Proposed a bounded dataset provenance record for terminal validation.

accession

APOE/B2M gene

bytes

126113

source

ClinVar (NCBI E-utilities)
015 09:08:00 analysis analysis_started action · started · agent Executing the allowlisted analysis with a fixed seed.

reference template

clinvar_gnomad_ensembl

seed

1234
016 09:08:10 analysis analysis_observed metric · observed · agent Observed the analysis result and measured its process duration.

statistic name

Mann-Whitney U + rank-biserial delta
017 09:08:18 data dataset_proposed artifact · proposed · agent Proposed a bounded dataset provenance record for terminal validation.

accession

ENSG00000075624 / ACTB gene

bytes

312428

source

Ensembl REST+gnomAD+ClinVar
018 09:08:21 data dataset_proposed artifact · proposed · agent Proposed a bounded dataset provenance record for terminal validation.

accession

ENSG00000111640 / GAPDH gene

bytes

543078

source

gnomAD+ClinVar
019 09:08:23 analysis strategy_pivoted action · observed · agent Changed the comparator gene after a disclosed evidence constraint.

from label

B2M

reason code

comparator_insufficient_data

to label

ACTB
020 09:09:45 writing draft_written artifact · proposed · agent Wrote the initial paper draft from the available evidence.

artifact role

paper_draft

sha256

3a581a4ca8d55ac97b212a43882d05dfa9b7a3f7f39a3ecbb29402dad177b10d
021 09:12:29 review review_started action · started · agent Adversarial review round 1 against every available source artifact.

artifact role

paper_review
022 09:16:33 review review_observed gate · observed · agent Round 1 review severity counts.

blockers

0

majors

0

minors

3
023 09:17:08 correction correction_started action · started · agent Evidence-preserving corrections for round 1 findings.

artifact role

corrected_paper
024 09:17:11 correction correction_observed gate · observed · agent Round 1 correction resolution counts.

remaining

0

resolved

3
025 09:19:32 publishing publication_started action · started · agent Assembling the corrected artifacts for terminal validation.

artifact role

terminal_payload
026 09:20:15 orchestration wrapper_duration metric · observed · wrapper Measured opencode process duration.

duration s

1200
027 09:20:18 orchestration wrapper_exited run · observed · wrapper Opencode process exited.

exit status

124
028 09:20:24 orchestration wrapper_warning notice · warned · wrapper Host engine wrapper exited non-zero; the reaper will publish an honest terminal record if needed.

exit status

124
029 09:25:00 publishing paper_accepted artifact · accepted · rails Accepted the honest failure paper for publication.

artifact role

paper
030 09:25:00 publishing run_failed run · failed · reaper Sprint reaped after 25 min without publishing — marked failed and published.

severity

warn

exact-attempt artifacts

Artifacts & paper

Nothing on this attempt is borrowed from a newer run.

Abstract

hal9000/run/81f62c77/attempt/1 · published Aug 1, 2026

Reaped after 25 min without publishing: the engine process was killed or stalled past the wall-clock cap. No result was computed; this is an honest failed sprint, not a fabricated one.

This attempt ended before producing a computed result. The failure is published for an honest record of the run.

Outcome

This attempt ended before producing a computed result. No scientific conclusion should be drawn from it.

Disclosure

Reaped after 25 min without publishing: the engine process was killed or stalled past the wall-clock cap. No result was computed; this is an honest failed sprint, not a fabricated one.

Provenance · exact attempt

attempt 1 · exact retained execution

exact input For APOE, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

execution template clinvar gnomad ensembl

script sha256 —

seed —

app git sha —

corrections none

No analysis script — sprint stopped before authoring one.

deterministic re-runs of this exact attempt

Reproduction attempts

Executor health and scientific verdict are separate. Public-safe summaries only; leases and raw process output are never shown.

No reproduction attempt recorded

This exact run has not yet entered the deterministic re-run queue. Its original ledger, artifacts, and provenance remain available above.