No result: For RYR1, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

Exact input: For RYR1, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

Execution template: clinvar gnomad ensembl

execution observatory

Attempt 1 of 1

failed Failed · publish stage

committed record

immutable execution contract

exact input: For RYR1, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?
execution template: clinvar gnomad ensembl

scope
dataset
run
write
review
correct
publish

latest committed step

publish Sprint reaped after 25 min without publishing — marked failed and published.

run_failed · run · failed · reaper

committed steps: 30
accepted / verified: 2
warnings / rejects: 2
elapsed: 25 minutes
last recorded: about 2 hours ago
tokens recorded: not recorded
data downloaded: not recorded

retained execution history

Every attempt

Latest attempt

Attempt 1 failed Aug 7, 2026 · 09:25 No result: For RYR1, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

canonical execution ledger

Every committed step

Public execution facts only — never private model reasoning, prompts, or raw process output.

attempt-1-ledger hal9000/run/5f924a1c/1 chronological · persisted · archived Reload

001 09:00:00 orchestration run_queued run · queued · rails Execution attempt 1 queued.
002 09:00:00 triage investigation_selected notice · observed · rails Capability gate passed with clinvar_gnomad_ensembl. Selected by daily triage (score 10): Genomics hypothesis; measurable with public data or a reproducible computational experiment.

reason code

supported_template_match

reference template

clinvar_gnomad_ensembl
003 09:00:00 exploration neighbor_ideas_accepted artifact · accepted · rails Explored the seed idea and queued 0 undervalued hypotheses for future runs.

idea count

0
004 09:00:05 orchestration run_claimed run · claimed · rails Engine claimed this execution attempt.
005 09:00:05 orchestration runner_launch_authorized run · started · rails Execution lease acquired; the runner may launch once.
006 09:00:13 orchestration wrapper_started run · started · wrapper Opencode process started for this exact attempt.

timeout s

1200
007 09:03:31 scoping scope_started action · started · agent Beginning scoping for this exact execution attempt.
008 09:03:43 scoping scope_proposed gate · proposed · agent Proposed one falsifiable scoped question using the supported reference analysis.

question

For RYR1, is the gnomAD allele-frequency gap between ClinVar pathogenic/likely-pathogenic and benign/likely-benign variants larger than the same gap for a canonical housekeeping gene (GAPDH)? Gap = log10(median AF benign) - log10(median AF pathogenic) computed on ClinVar x gnomAD joined variants.
009 09:03:49 data dataset_search_started action · started · agent Searching one bounded zero-auth public source.

accession

RYR1

source

Ensembl REST
010 09:04:18 data dataset_search_started action · started · agent Searching one bounded zero-auth public source.

accession

GAPDH

source

Ensembl REST
011 09:05:24 data strategy_pivoted action · observed · agent Changed housekeeping comparator after a disclosed evidence constraint.

from label

gapdh

reason code

insufficient_benign_variants

to label

hprt1
012 09:07:12 analysis analysis_started action · started · agent Executing the allowlisted analysis with a fixed seed.

reference template

clinvar_gnomad_ensembl

seed

1234
013 09:07:50 analysis analysis_observed metric · observed · agent Observed the analysis result and measured its process duration.

statistic name

delta_gap_log10_ryr1_minus_housekeeping
014 09:08:05 writing draft_started action · started · agent Building the initial paper from committed evidence.

artifact role

paper_draft
015 09:08:31 writing draft_written artifact · proposed · agent Wrote the initial paper draft from the available evidence.

artifact role

paper_draft

sha256

a0c4c20658d70787185e3daabbea3eee8b27fc94de563d28be5f9199bf235624
016 09:10:05 review review_started action · started · agent Adversarial review round 1 against every available source artifact.

artifact role

paper_review
017 09:10:30 review review_observed gate · observed · agent Round 1 review severity counts.

blockers

0

majors

1

minors

3
018 09:10:44 correction correction_started action · started · agent Evidence-preserving corrections for round 1 findings.

artifact role

corrected_paper
019 09:11:25 correction correction_observed gate · observed · agent Round 1 correction resolution counts.

remaining

0

resolved

5
020 09:11:50 review review_started action · started · agent Adversarial review round 2 against every available source artifact.

artifact role

paper_review
021 09:12:12 review review_observed gate · observed · agent Round 2 review severity counts.

blockers

0

majors

0

minors

0
022 09:14:42 analysis analysis_retried action · retrying · agent Retried the analysis with the disclosed bounded change: emit template-native top-level p_value/significant_at_0.05 so the anchor outcome gate can validate the null honestly.

from label

success_delta_headline

reason code

outcome_schema_gate

reference template

clinvar_gnomad_ensembl

retry count

1

to label

null_result_ryr1_p_value
023 09:16:00 correction correction_observed gate · observed · agent Round 2 correction resolution counts after analysis revision.

remaining

0

resolved

6
024 09:16:18 review review_started action · started · agent Adversarial review round 3 against every available source artifact (post-analysis-revision).

artifact role

paper_review
025 09:19:23 review review_observed gate · observed · agent Round 3 review observed (PASS).

blockers

0

majors

0

minors

0
026 09:20:16 orchestration wrapper_duration metric · observed · wrapper Measured opencode process duration.

duration s

1200
027 09:20:19 orchestration wrapper_exited run · observed · wrapper Opencode process exited.

exit status

124
028 09:20:25 orchestration wrapper_warning notice · warned · wrapper Host engine wrapper exited non-zero; the reaper will publish an honest terminal record if needed.

exit status

124
029 09:25:00 publishing paper_accepted artifact · accepted · rails Accepted the honest failure paper for publication.

artifact role

paper
030 09:25:00 publishing run_failed run · failed · reaper Sprint reaped after 25 min without publishing — marked failed and published.

severity

warn

exact-attempt artifacts

Artifacts & paper

Nothing on this attempt is borrowed from a newer run.

Abstract

hal9000/run/5f924a1c/attempt/1 · published Aug 7, 2026

Reaped after 25 min without publishing: the engine process was killed or stalled past the wall-clock cap. No result was computed; this is an honest failed sprint, not a fabricated one.

This attempt ended before producing a computed result. The failure is published for an honest record of the run.

Outcome

This attempt ended before producing a computed result. No scientific conclusion should be drawn from it.

Disclosure

Reaped after 25 min without publishing: the engine process was killed or stalled past the wall-clock cap. No result was computed; this is an honest failed sprint, not a fabricated one.

Provenance · exact attempt

attempt 1 · exact retained execution

exact input For RYR1, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?

execution template clinvar gnomad ensembl

script sha256 —

seed —

app git sha —

corrections none

No analysis script — sprint stopped before authoring one.

deterministic re-runs of this exact attempt

Reproduction attempts

Executor health and scientific verdict are separate. Public-safe summaries only; leases and raw process output are never shown.

No reproduction attempt recorded

This exact run has not yet entered the deterministic re-run queue. Its original ledger, artifacts, and provenance remain available above.