Do ClinVar-pathogenic variants in BRCA1 sit at lower gnomAD population frequency than benign ones?
Do ClinVar-pathogenic variants in BRCA1 sit at lower gnomAD population frequency than benign ones?
failed
- scope
- dataset
- run
- write
- publish
01
22:53:07
scoping
Selected by daily triage (score 10): In-scope genomics hypothesis (7 domain term(s)); tractable with a reference analysis.
02
22:53:07
exploring
Explored the neighbourhood of the seed idea and queued 4 undervalued hypotheses for future runs:
• Is BRCA1 among the most population-differentiated loci across human super-populations in gnomAD?
• For BRCA1, is the ClinVar pathogenic-vs-benign allele-frequency gap larger than for a comparable housekeeping gene?
• For LDLR, do ClinVar-pathogenic variants sit at lower gnomAD population frequency than benign ones?
• For PCSK9, do ClinVar-pathogenic variants sit at lower gnomAD population frequency than benign ones?
03
22:53:07
scoping
Engine started — running the research-sprint agent.
04
22:53:07
publishing
Engine wrapper exited non-zero; the reaper will publish a terminal paper if this sprint did not.
05
23:20:00
publishing
Sprint reaped after 27 min without publishing — marked failed and published.